2010-05-26 · In healthy volunteers and under rest, normal copeptin levels have 4.0-4.4 pmol/l as range with only 5% of values lying outside this range . Statistical analysis. A logarithmic transformation was performed to obtain a normal distribution for skewed variables (i.e. copeptin concentrations).

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It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes. Reference Range (s) <3 Years. Not Established. Baseline Copeptin value of ≥ 21.4 pmol/L identify patients with Nephrogenic Diabetes Insipidus with 100% Sensitivity and Specificity. 3 A second Copeptin measurement after fluid deprivation provides the following excellent results: References 1 Morgenthaler NG, Struck J, Jochberger S, Dü nser MW, Copeptin: clinical use of a new biomarker. Copeptin (median, 4.2 pmol/L; range, 1–13.8 pmol/L) was detectable in 97.5% of 359 healthy individuals and was not associated with age. Median concentrations were considerably higher in men than women, increased significantly after exercise, and were influenced by fasting and water load.

TEST. A A A During arginine stimulation, clinical and laboratory parameters remained generally stable and in the normal range. Seven patients (all with diabetes insipidus) had mild hypernatraemia (range 146–149 mmol/L) at the end of the test. Overall, the test burden was low, although nausea was a frequent symptom during arginine stimulation. As a Control Group, 30 healthy individuals with normal physical examination results were included.

13, 33 The difference in gender is poorly understood. Copeptin combined with hypersensitive cardiac troponin T (hs-cTnT) is a new detection scheme, and its value in the early diagnosis of acute myocardial infarction is still unclear. Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction.

Swiss Medical Weekly - Copeptin-based diagnosis of diabetes 23 Diabetes insipidus Diabetes Insipidus: What You Need to Know | The Healthy. Diabetes

Normal range of copeptin. The normal range for copeptin is now well defined.

Jan 8, 2009 The present study sought to identify confounding factors for the interpretation of copeptin levels in healthy individuals. The natriuretic peptides

När den myocardial infarction by copeptin and troponin: the Pro-Core registry. BMJ Open. The association between normal-range admission potassium in cardiac surgery: with special reference to mixed venous oxygen saturation and natriuretic Copeptin Release in Cardiac Surgery: A New Biomarker to Identify Risk Perioperative NT-proBNP levels in CABG with and without concomitant normal copeptin concentration preoperatively and uneventful course, the postoperative copeptin concentrations decreased to normal values within 3-to-4 days M. I. Smaradottir et al., "Copeptin and coronary artery calcium score in elderly A. Wang et al., "Dynamics of testosterone levels in patients with newly and a matched normal population," British Journal of Haematology, vol. Subcategorizing the Expected Value of Perfect Implementation to Identify When and Combined testing of copeptin and high-sensitivity cardiac troponin T at Heart failure with normal ejection fraction is uncommon in acute myocardial European Geriatric Medicine - 2013-01-01. Levels of copeptin among elderly patients in relation to systolic heart failure and heart failure with normal ejection.

Patients in the "normal cohort" had copeptin concentration at weaning from CPB of 194 pmol/L (98-275), postoperative day 1, 27 pmol/L (18-31); and day 3, 8.9 pmol/L (6.3-12). CONCLUSIONS: Regardless of cardiac surgical procedure and perioperative course, all patients had an early significant rise of copeptin concentrations, generally peaking at weaning from CBP or upon arrival in the intensive care unit. Conversely, during hypotonic saline infusion, plasma osmolality decreased and copeptin decreased to values in the very low normal range. Ref-21 Electroloyte disturbances are common in cardiovascular and renal diseases, including the most commonly seen hyponatremia, and the pathophysiology is complex and the diagnostic approach is challenging. Copeptin values according to normal plasma osmolality: Concentration range Intra-assay CV % Inter-assay CV % 2.0 – 4.0 pmol/L < 15.0 % < 18.0 % 4.0 – 15 pmol/L < 8.0 % < 10.0 % 15 – 50 pmol/l < 4.0 % < 5.0 % > 50 pmol/L < 3.0 % < 5.0 % Out of range samples (> 500 pmol/L) < 4.0 % < 6.0 % The normal range of plasma copeptin levels is from 1.0 to 13.8 pmol/l with higher median levels in men than in women according to two large physiological studies in healthy volunteers [26, 43]. The difference in gender is poorly understood, also because no significant changes during the menstrual cycle were observed [ 44 ].
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It is a reliable surrogate marker for arginine vasopressin (AVP).

The copeptin test measures the amount of copeptin in the blood. Copeptin is a polypeptide that is released as part of normal ADH production in the body. Measurement of copeptin is an effective surrogate for measurement of ADH. The advantages of testing for copeptin over ADH is that it is more stable and is easier to measure in the lab.
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Normal values and physiological response of plasma copeptin in healthy volunteers The reference range for copeptin was first defined in a study with 359 healthy volunteers. This study showed the broad range of copeptin values. The median copeptin plasma concentration was 4.2 pmol/L with a range between 1 and 13.8 pmol/L.

Copeptin combined with hypersensitive cardiac troponin T (hs-cTnT) is a new detection scheme, and its value in the early diagnosis of acute myocardial infarction is still unclear. Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction. The cut-off level of copeptin was 4.4 pmol/L, whereas in ambulatory patients with central diabetes insipidus and patients with post-surgical central diabetes insipidus copeptin levels < 2.6 pmol/L and < 2.9 pmol/L, respectively, diagnosed diabetes insipidus [29, 30]. Indeed, recent studies have found promise in its use in managing sepsis as copeptin levels were found to distinguish normal controls from septic patients, and septic patients from septic shock patients [44]. It may also hold promise as a cardiology biomarker in conjunction with troponin for acute myocardial infarction rule out [45,46]. Patients were analyzed as a whole cohort (n = 20) and in a restricted "normal cohort" consisting of patients with normal preoperative copeptin concentration (<10 pmol/L) and perioperative uneventful course (n = 11). In the whole cohort, preoperative copeptin concentration was 7.0 pmol/L (interquartile range: 3.1-11 pmol/L).